Therapeutic Drug Monitoring (TDM) in Renal Transplant (RT): Reasons to Choose the LC-MS/MS Method
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چکیده
منابع مشابه
Therapeutic drug monitoring (TDM) of atazanavir in pregnancy
Methods In this prospective, open labelled study, pregnant HIVpositive women received ATV/r as part of their routine pre-natal care. Demographic and clinical data were collected, and ATV plasma concentrations [ATV] were determined in the first (T1) and/or second (T2) and/or third (T3) trimester using HPLC-MS/MS (LLQ = 0.05 μg/mL). Postpartum (PP) sampling was performed where applicable. Antepar...
متن کاملTherapeutic Drug Monitoring of Sirolimus,Correlation With Laboratory Parameters In Transplant Patients
Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...
متن کاملCurrent role of LC-MS in therapeutic drug monitoring.
The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics....
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Background & Aim: Cyclosporine-A (CsA) is an immunosuppressant with a narrow therapeutic window. Inter-and-intrapatient variability in cyclosporine pharmacokinetics necessitates frequent blood level monitoring in transplant patients and total blood cyclosporine concentration used to allow dosage adjustment in transplant patients. The purpose of the present study was, first of all, to develop ...
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204. Voriconazole Restriction in Addition to Therapeutic Drug Monitoring (TDM) Protocol Results in Optimized Dosing Natasha Pettit, PharmD; Zhe Han, PharmD; Mildred Vicente, PharmD; Emily Landon, MD; Jennifer Pisano, MD; Allison H. Bartlett, MD, MS; Pharmacy Services, University of Chicago Medicine, Chicago, IL; Pharmacy Services, University of Chicago Medicine, Chicago, IL; Infectious Diseases...
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ژورنال
عنوان ژورنال: Journal of Chromatography & Separation Techniques
سال: 2012
ISSN: 2157-7064
DOI: 10.4172/2157-7064.1000e101